Which of the following is a feature of delirium that can help differentiate it from dementia quizlet?

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Delirium Delirium Delirium is an acute, transient, usually reversible, fluctuating disturbance in attention, cognition, and consciousness level. Causes include almost any disorder or drug. Diagnosis is clinical... read more (sometimes called acute confusional state) and dementia Dementia Dementia is chronic, global, usually irreversible deterioration of cognition. Diagnosis is clinical; laboratory and imaging tests are usually used to identify treatable causes. Treatment is... read more are the most common causes of cognitive impairment, although affective disorders (eg, depression) can also disrupt cognition. Delirium and dementia are separate disorders but are sometimes difficult to distinguish. In both, cognition is disordered; however, the following helps distinguish them:

  • Delirium affects mainly attention.

  • Dementia affects mainly memory.

  • Delirium is typically caused by acute illness or drug toxicity (sometimes life threatening) and is often reversible.

  • Dementia is typically caused by anatomic changes in the brain, has slower onset, and is generally irreversible.

Delirium often develops in patients with dementia. Mistaking delirium for dementia in an older patient—a common clinical error—must be avoided, particularly when delirium is superimposed on chronic dementia. No laboratory test can definitively establish the cause of cognitive impairment; a thorough history and physical examination as well as knowledge of baseline function are essential.

Which of the following is a feature of delirium that can help differentiate it from dementia quizlet?

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Which of the following is a feature of delirium that can help differentiate it from dementia quizlet?

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Which of the following is a feature of delirium that can help differentiate it from dementia quizlet?

D. 65-year-old African American man with hypertension.

Nonmodifiable risk factors for stroke include age (older than 65 years), male gender, ethnicity or race (incidence is highest in African Americans; next highest in Hispanics, Native Americans/Alaska Natives, and Asian Americans; and next highest in white people), and family history of stroke or personal history of a transient ischemic attack or stroke. Modifiable risk factors for stroke include hypertension (most important), heart disease (especially atrial fibrillation), smoking, excessive alcohol consumption (causes hypertension), abdominal obesity, sleep apnea, metabolic syndrome, lack of physical exercise, poor diet (high in saturated fat and low in fruits and vegetables), and drug abuse (especially cocaine). Other risk factors for stroke include a diagnosis of diabetes mellitus, increased serum levels of cholesterol, birth control pills (high levels of progestin and estrogen), history of migraine headaches, inflammatory conditions, hyperhomocystinemia, and sickle cell disease.

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Terms in this set (144)

What is the DSM V proper term for DELIRIUM and DEMENTIA?

Major neurocognitive disorders

What did DSM V classification of "Major Neurocognitive Disorders" replace?

Delirium and dementia

What is DELIRIUM in terms of:
1) Consciousness
2) Other problems
3) Acuity
4) Three things it affects
5) Main goal in treatment

1) Altered consciousness
2) Associated with lot of other problems
3) Generally ACUTE or SUBACUTE
4) Cognition, perception and attention
5) Usually delirium caused by some other condition so want to figure what is causing the delirium and fix it

What is the MAIN GOAL of delirium treatment? Why?

Delirium usually caused by some other medical condition so goal is to TREAT THAT condition and therefore eliminate the delirium

In terms of DEMENTIA, describe:
1) Progress
2) Memory loss
3) Advanced stages

1) Slow and insidious
2) More SHORT-TERM than long-term memory loss
3) Starts to affect overall cognition

What type of memory loss is more common in dementia, especially early stage?

Short-term memory loss

When does HIGHER CORTICAL FUNCTIONING get affected in dementia usually?

Later stages

Describe the difference between DELIRIUM and DEMENTIA in terms of:
1) Onset
2) Duration
3) Cause
4) Course/reversibility
5) Effect at night
6) Attention
7) Level of consciousness
8) Orientation to place and time
9) Use of language
10) Memory
11) Need for medical attention

DELIRIUM
1) Usually sudden with definite beginning point (usually definitive end point as well)
2) Usually days to weeks
3) Almost always another condition (i.e drugs, infection, sickness, dehydration etc.)
4) Usually reversible
5) Almost always worse (sun-downing)
6) Greatly impaired (can be lucid one moment and then very confused next)
7) Variably impaired
8) Varies
9) Slow and often incoherent and inappropriate
10) Varies
11) Immediately required

DEMENTIA
1) Slow and gradual (no real ending point)
2) Usually permanent condition
3) Usually chronic disorder of the brain
4) Usually progressive and irreversible
5) Often worse (sun-downing)
6) Usually not impaired (unless later stages)
7) Unimpaired usually unless severe
8) Usually impaired
9) Sometimes difficulty finding the right word
10) Lost, especially short-term
11) Required but less urgent

Is DELIRIUM or DEMENTIA usually more sudden in onset?

Delirium

Is DELEIRIUM or DEMENTIA usually associated with definitive end point?

Delerium

Is DEMENTIA or DELIRIUM associated with permanent condition?

Dementia

Is DEMENTIA or DELIRIUM usually associated to another medical condition or underlying cause?

Delirium

Is DEMENTIA or DELIRIUM usually associated to being reversible?

Delirium

Is DEMENTIA or DELIRIUM usually worse at night? What is this called?

- Both (but more likely to be delirium)
- Sundowning

Is DEMENTIA or DELIRIUM associated with altered consciousness?

- Delirium (though can be for dementia later stages)

Is DEMENTIA or DELIRIUM usually disoriented to time and place?

Dementia

Is DEMENTIA or DELIRIUM characterized by incoherence and inappropriate use of language?

Delirium

Is DEMENTIA or DELIRIUM characterized by loss of words?

Dementia

Is DELIRIUM or DEMENTIA characterized by short-term memory loss often?

Dementia

Is DELIRIUM or DEMENTIA more indicated for immediate medical attention?

Delirium

In terms of DELIRIUM DSM V DEFINITION describe:
1) What is the disturbance in
2) What is there a decrease in (2)
3) Development
4) What is it a change from
5) What can patients do
6) Other problems associated
7) Evidence

1) Disturbance in ATTENTION
2) Decrease in AWARENESS and CONSCIOUSNESS
3) Over SHORT PERIOD OF TIME (hours to days)
4) It is a change from BASELINE
5) Fluctuate
6) Other cognition problems (language, orientation etc.)
7) HISTORY and/or WORKUP shows evidence that it is caused by direct physiological effect of something (i.e drug, toxin, medical condition etc.) rfc

In terms of DELIRIUM TYPES, describe what is:
1) Substance intoxication delirium
2) Substance withdrawal delirium
3) Medication-induced delirium
4) Delirium due to another medication condition
5) Delirium due to multiple etiologies

1) Intoxication via a substance causing delirium
2) Withdrawal from something (i.e alcohol) causes delirium
3) Number one cause in hospital and basically a medication (i.e benadryl or pain medication) causes delirium
4) Some documented medical condition causes the delirium
5) Multiple causes

What is the NUMBER ONE cause of delirium in a hospital? * VERY IMPORTANT*

Medication-induced delirium

What are FIVE types of delirium?

1) Substance intoxication delirium
2) Substance withdrawal delirium
3) Medication-induced delirium
4) Delirium due to another medical condition
5) Delirium due to multiple etiologies

What must you specify (2) with delirium?

1) Specify if ACUTE (few hours to days) or PERSISTENT (weeks to months)
2) HYPERACTIVITY (agitated) or HYPOACTIVITY (lethargic) or MIXED ACTIVITY

True/False: Delirium always include hyperactivity

False (can be hypoactivity, hyperactivity or even mixed)

What type of delirium lasts several weeks?

Persistent

What type of delirium lasts three days?

Acute

What is DELIRIUM considered in medicine? Why?

- Medical emergency
- Can lead to death or irreparable harm quickly if not treated

True/False: Delirium is considered a medical emergency

True

Describe DELIRIUM'S EFFECT on:
1) Hospital stay
2) Morbidity
3) Mortality

1) Increases
2) Increases
3) Increases

In terms of DELIRIM, describe:
1) Prevalence
2) Recognition
3) How can 30% of cases be prevented

1) 15 - 60%
2) Often unrecognized by staff (70% of cases not diagnosed)
3) Changing care routines

What is the number one consult in psychiatry?

Delirium

In terms of PREDISPOSING FACTORS of DELIRIUM, describe:
1) Age
2) Medication
3) Medical conditions
4) Dementia
5) Social
6) Other substances
7) Hopitlization

1) Older age means more likely to get delirium
2) Medication use, especially polypharmacy
3) Chronic medical conditions
4) Prexisting dementia
5) Social isolation (includes sensory loss like blind/deaf)
6) Intoxication via other substances, illegal or legal
7) Hospitalized with acute toxic, metabolic or traumatic CNS disorders

What type of medications often give DELIRIUM?

* VERY IMPORTANT *

Anticholinergics

What type of disabled people are likely to get dementia?

Those who are socially isolated like DEAF or BLIND

Do older or younger people tend to have delirium?

Older

What is the single most common pharmacological cause of delirium?

* VERY IMPORTANT *

Anticholinergic medicines

In terms of the COURSE of delirium, describe:
1) Over what time period it usually develops
2) What can it progress to (3)
3) What does it increase risk of (3)

1) Hours to days
2)
- Can be SELF-LIMITED
- Can stretch to weeks
- Can lead to DEATH
3) Other medical problems like pneumonia, ulcers (i.e bed ulcers) and poor recovery from underlying general medical condition

What is usually the cause of delirium?

Some underlying medical condition

In terms of ASSOCIATED FEATURES of DELIRIUM, describe:
1) Sleep
2) Behavior
3) Emotion

1) Disturbances in sleep-wake cycle (no idea if it is day or night and sundowning)
2) Psychomotor behavior changes leading to HYPERACTIVITY or HYPOACTIVITY
3) Emotional disturbances (irritability, apathy, euphoria etc.)

In terms of DELIRIUM CAUSES, describe the common reversible factors

D - Drugs (prescription and illicit)
E - Electrolyte imbalance (i.e dehydration)
L - Lack of drugs (i.e withdrawal usually from alcohol, benzos and barbituates)
I - Infection (i.e delirium for elderly people with UTI)
R - Reduced sensory input (i.e vision or hearing)
I - Intracranial (i.e stroke, subdural hematoma or CNS infection)
U - Urinary retention and/or fecal imapction (especially elderly and post-op)
M - Myocardial or Pulmonary problems

Delirium caused by DELIRIUM

How can DEHYDRATION cause DELIRIUM?

There is electrolyte imbalance

Withdrawal from what three things often causes delirium?

- Alcohol
- Benzodiazepines
- Barbituates

Describe the difference in possibilities for UTI for elderly and young people?

- In young people, usually just causes discomfort and can be treated relatively easily
- In older people, can cause DELIRIUM

What is the number 1 cause of reversible delirium?

Medication

Many times, things that affect the _______ cause delirium

central nervous system (CNS)

What is the most common infection that causes delirium?

UTI

True/False: A head injury can lead to delirium but not dementia

False (Can lead to both delirium or dementia)

A person with dementia is more prone to get ______ than a "normal person"

- delirium

True/False: Hyperthyroidism or hypothyroidism can both lead to delirium

True

Hyperthyroidism leads to _______ delirium

hypoactive

In terms of blood sugar, ______ or _____ can lead to delirium

- hypoglycemia
- hyperglycemia

Essentially, any ______ in the body can lead to delirium

abnormality

Are tumors more likely to lead to dementia, delirium or both equally?

Dementia

What are two types of PRIMARY BRAIN tumors? What are they likely to lead to: dementia or delirium? Which one is treatable and which one is not as responsive to therapy?

- Meningioma and glioma
- Both likely to lead to dementia
- MENINGIOMA is treatable but GLIOMA is less responsive

What is DEMENTIA PUGILISTICA?

People with repeated head trauma (i.e boxers) more likely to get dementia

What type of dementia do boxers normally get? Why?

- Dementia pugilistica
- Repeated head trauma

What is an important factor to consider in terms of DELIRIUM and DEMENTIA?

Environment

Describe how the HOSPITAL SETTING can affect delirium? What should be done to help this?

- The hospital environment (i.e busy nature of ICU) can cause psychosis/delirium
- Have family member or loved one nearby to have constant familiar face

In terms of a MEDICAL WORK-UP of DELIRIUM, describe:
1) What you start with
2) What you have to do often with step 1)
3) What you do next
4) What you can do

1) History and physical
2) Employ help of NURSES or FAMILY MEMBERS/CARE GIVERS as patient not always good historian
3) Battery of lab tests (i.e CBC, UA/UC, thyroid, drug screen etc.)
4) Can do MRI, CAT, LP etc.

In terms of TREATING DELIRIUM, describe:
1) What is the main priority
2) What the symptoms are treated with and caveat

* VERY IMPORTANT *

1) Treat the underlying cause (i.e treat the low sodium or something else thought to cause it)
2)
- Treat with IV haloperidol UNLESS alcohol/benzodiazepine withdrawal then give tapered benzos

What drug is often given to delirious patients to treat it? What route and why? What is the caveat?

* VERY IMPORTANT *

- Often given IV HALOPERIDOL
- Given IV and not PO because PO patient would probably spit it at you
- Can't give it alcohol/benzodiazepine withdrawal patients because just give tapered benzodiazepine to them

True/False: In all cases of delirium, IV haloperidol can be used as symptomatic treatment

False (in all cases but alcohol/benzodiazepine withdrawal in which case you give benzodiazepine in tapered levels)

In terms of DELIRIUM, what is it symptomatically treated with? Describe frequency. Describe different doses

- IV haloperidol (unless alcohol or benzodiazepine withdrawal then taper patient with benzodiazepine)
- Given once and reassessed every 30 minutes
- MILD AGITATION OR ELDERLY given .5-2mg, MODERATE is 2-5mg and SEVERE is 5-10mg

What is the drug of choice for DELIRIUM patients? What can be used if PO is an option often?

- IV haloperidol
- PO Risperidone (atypical antipsychotic)

If someone is going through ALCOHOL WITHDRAWAL and has DELIRIUM, describe:
1) What show be used to look at signs and symptoms
2) What should you treat them with and what should you NOT use

1) CIWA score
2) Use benzodiazpine to taper them off (do NOT use IV haloperidol)

What are NON-MEDICATION important things to do in treatment of delirium (4)?

- Reorient patient (say nurses name, doctors name, clock in room etc)
- Well-lit room with windows to see night and day
- Limit unnecessary stimuli especially in the night
- Mobilize patient (OOB = out of bed)

In terms of MAJOR NEUROCOGNITIVE DISORDER, describe:
1) Another name for it
2) General definition
3) What it cannot be caused by

1) Dementia
2) Significant cognitive decline from previous level and affects ability to be independent in life and usually one or more cognitive domains
3) Delirium

What is key to remember about the cognitive decline in DEMENTIA patients (2)?

* VERY IMPORTANT *

- It is a decline from previous baseline
- it affects ability to be INDEPENDENT in everyday life

If someone gets confused because of polypharmacy, is that DEMENTIA or DELIRIUM probably?

Delirium

What is something similar to dementia but caused because of depression? Is this considered to be a type of dementia?

- Pseudodementia
- No

What is PSEUDODEMENTIA?

Dementia-like symptoms caused by depression

What TWO things should be specified in MAJOR NEUROCOGNITIVE DISORDERS (aka dementia)?

- Specify WITH or WITHOUT behavioral disturbances
- Specify if MILD, MODERATE or SEVERE

If someone with dementia has behavioral disturbances caused by the frontal lobe they might try to ______ or be _____

- expose themselves
- combative

What is the most COMMON type of dementia?

Alzheimer's disease

What is another name for PICK'S DISEASE? What happens?

- Frontotemporal lobar degeneration
- Affects FRONTAL and TEMPORAL lobe

What is another term for FRONTOTEMPORAL LOBAR DEGENERATION?

Pick's disease

What is the SECOND MOST common form of dementia?

Vascular disease causing dementia

What is the first and second most common form of dementia?

- FIRST is Alzheimer's Disease
- SECOND is due to vascular disease

What is characteristic of the SECOND MOST common type of dementia? What is it called?

- Stepwise decline in cognitive function due to multiple strokes
- Dementia due to vascular disease

True/False: HIV/AIDS cannot cause dementia

False (it can if it gets into CNS)

What is an example of a PRION DISEASE that causes DEMENTIA?

Crutzfield- Jakub

True/False: Dementia can be caused by Huntington's Disease

True

In terms of MILD NEUROCOGNITIVE DISORDER, describe what it is

Cognitive and memory problem is more modest and doesn't affect ability to live independent but WORSE than normal aging

Describe difference between normal aging and the two types of neurocognitive disorders

NORMAL AGING
- Normal memory loss and cognition loss associated with general population

MINOR NEUROCOGNITIVE DISORDER
- Cognition and memory loss that is WORSE than normal aging but DOES NOT affect ability to live independently usually (so less than dementia)

MAJOR NEUROCONGITIVE DISORDER (i.e dementia)
- Cognition and memory loss that affects ability to be independent

In terms of DEMENTIA, describe:
1) It is usually an _____ disorder
2) Normal onset age
3) Onset
4) Age relation
5) What type of patients (2) are more likely to have it
6) % that have it who are 65-70
7) % that have it who are 75 - 85
8) & that have it who are 90

1) Acquired
2) Older than 65
3) Gradual or stepwise that is progressive
4) Older you are, the more likely you are to have dementia
5)
- Hospitalized
- Medically ill
6) 10%
7) 25%
8) 50%

True/False: Some dementia types are more likely to have early onset while some are likely to have late onset

True

In terms of EARLY FEATURES of DEMENTIA, describe:
1) Changes are seen in ______ subtly
2) Interests
3) Emotion
4) Intellectual skills
5) Noticeability

1) Personality
2) Decreased range of interests
3) Apathetic and shallow emotions
4) Gradually affected and may not be noticed
5) May not be noticed really

In terms of EARLY DEMENTIA, what signs are seen (4)? Are these very noticeable?

- Subtle changes in personality, emotional affect decreased, subtle changes in intellect, decreased interest ranges
- Not very noticeable

In terms of LATER FEATURES of DEMENTIA, describe:
1) There are more _______
2) Exaggerated changes in ______
3) What skills are lost
4) Other symptoms often associated

1) Pronounced cognitive impairment
2) Personality and mood
3) Social skills lost
4) Psychotic symptoms often seen

Are more noticeable changes seen in EARLY or LATE dementia?

Late

In terms of ADVANCED DEMENTIA, describe:
1) Inability to perform _____
2) Develop _____
3) Emotion
4) What they forget
5) End stage and what happens

1) Activities of daily living (ADL)
2) Incontinence
3) Very emotionally labile
4) Names of friends and sometimes family
5)
- Usually MUTE and UNRESPONSIVE
- Usually die within 1 year

Differentiate generally the three stages of DEMENTIA

EARLY
- Subtle changes in intellect and personality

LATER
- Cognitive impairment more pronounced, social skills lost and may have psychotic symptoms

ADVANCED
- Incontinence, inability to perform activities of daily living and eventually can become mute/unresponsive with death following 1 year after

What can usually indicate death within a year for DEMENTIA patients?

When they go mute/unresponsive

In terms of PSEUDODEMENTIA, describe:
1) What it mimics
2) What it is due to
3) What is important to remember about it

1) Dementia
2) Depression
3) Caused by DEPRESSION and it is REVERSIBLE (unlike most types of depression)

In terms of DEMENTIA vs PSEUDODEMENETIA describe:
1) Cause
2) Reversibility
3) Memory
4) Patient description of problems
5) Response to questions
6) Social skill loss
7) Mood changes

DEMENTIA
1) Usually some chronic brain disorder
2) Usually IRREVERSIBLE
3) Problems with memory but NOT as likely to complain
4) Less likely to describe in detail
5) Make up stuff
6) Usually LATE
7) Less apparent especially in beginning

PSEUDODEMENTIA
1) Depression
2) Usually REVERSIBLE
3) Problems with memory and APT to complain
4) More likely to describe in detail
5) Says "I don't know"
6) Usually EARLY
7) More present in the beginning

Are DEMENTIA or PSEUDODEMENTIA patients more likely to complain about memory problems?

Pseudodementia

If a patient responds with "I don't know" to every question, he or she probably has ______

* VERY IMPORTANT *

pseudodementia

Are PSEUDODEMENTIA or DEMENTIA patients more likely to lose social skills early on?

Pseudodementia

In terms of DIAGNOSING DEMENTIA, describe what three tests are done, what the scores mean and when should they be done

- MSE, MMSE or MoCA
- Under 25 is COGNITIVE IMPAIRMENT (lower the worse it is) and 30 is PERFECT
- Should be done daily in order to assess changes

In terms of DEMENTIA DIAGNOSTIC WORK UP, describe what should be done?

Similar to delirium in which you do battery of tests

What does RPR-VDLR test for?

Nuerosyphyllis

When should a CT/MRI be done for DEMENTIA patient?

Suspected mass lesion

When should EEG be done for DEMENTIA patients?

Suspected or known seizures

When should ABG be done for DEMENTIA patients?

Respiratory impairment

True/False: A SPECT or PET scan is a common test to run for dementia patients

False (not common since not that valuable and it is expensive)

In terms of ADVANCED ALZHEIMER'S DISEASE, we see _______ of brain matter

general wasting away

In terms of DEMENTIA, what is helpful for testing? What is the caveat though? Why is it helpful?

- Neuropscyhological testing
- Takes 4-5 hours
- Helps measure baseline and tell more specifically what type of dementia

What is NEUROPSYCHOLOGICAL TESTING used for? What type of patients is it good for?

- Helps determine baseline function for comparasion later and helps tell what type of dementia
- Good for HIGHLY educated patients

What type of testing is helpful to evaluate HIGHLY EDUCATED patients?

Neuropsychological testing

What is the DSM V name for the most common type of dementia?

Major neurocognitive disorder of the Alzheimer's type

In terms of ALZHEIMER'S DEMENTIA, describe:
1) DSM V name
2) Commonality (list in percentage too)
3) Onset

1) Major neurocognitive disorder of the Alzheimer's type
2) Most common type of dementia (aroud 50-60% of all cases)
3)
- EARLY onset is under 65 (usually familial with mutations on chromosome 21, 14 or 1)
- LATE onset is after 65

What is the difference, if any, between Alzheimer's dementia onset?

- EARLY onset is usually before 65 (usually familail with problems in chromosme 21, 14 or 1)
- LATE onset is usually after 65

What type of ALZHEIMER'S DEMENTIA would early onset be related to? What age does this happen usually?

- Familial (i.e problems with chromsomes 21, 14 or 1)
- Usually happens before 65, like in the 50s

In terms of ALZHEIMER'S DEMENTIA, describe:
1) Onset
2) % at 65 and % at 90
3) What it results in
4) When are physical findings seen? What are they (3)? What do they resemble?
5) What is often seen in late disease course in terms of other symptoms
6) What is seen on imaging in late stages usually?

1) Insidious (gradual and progressive) over months and years
2) 5% at 65 and 20% at 90
3) Near total collapse of intellectual functioning
4)
- Late stages
- Hyperrefelxia, frontal release signs and Babinski sign
- Resemble primitive reflexes
5) Often see PSYCHOTIC symptoms (i.e auditory or visual hallucinations)
6) Enlarged ventricles with cortical atrophy

Is cortical atrophy seen in LATE or EARLY Alzheimer's dementia?

Late

Is hyerreflexia and frontal release signs seen in EARLY or LATE Alzheimer's Dementia?

Late

How can a definitive diagnosis of Alzheimer's Dementia be done?

Post-mortem brain biopsy

True/False: Imaging can tell you definitively the diagnosis of Alzheimer's Dementia

False (must do post-mortem biopsy)

What are FIVE definitive things that tell you diagnosis of Alzheimer's Dementia?

ALL FROM POST-MORTEM BRAIN BIOPSY
1) Neurofibrillary tangles
2) Senile plaques
3) Granovascular degeneration of nerve cell bodies
4) Hirano bodies
5) Loss of cholinergic neurons

What type of neurons are often lost in ALZHEIMER'S PATIENTS? Where?

- Cholinergic neurons
- Basal forebrain pathways

In terms of ALZHEIMER'S DEMENTIA, describe risk factors in terms of:
1) Injury
2) Congenital disease
3) Social
4) Chromosome 19
5) Family

1) History of head injury
2) Down's syndrome
3) Low education or occupational leve
4) APOE e4 allele on chromosome 19 (increases risk and decreases age of onset)
5) 1st degree relatives with Alzheimer's Dementia

What chromosomal abnormality often causes people to be more predisposed to Alzheimer's Disease?

Down's syndrome

What is the relation between CHROMOSOME 19 and ALZHEIMER'S DISEASE?

Presence of APOE e4 allene on chromosome 19 causes INCREASED RISK and EARLIER ONSET of Alzheimer's Dementia1_

In terms of DEMENTIA WITH LEWY BODIES, describe:
1) What it is similar to and what it often gets misdiagnosed as?
2) Progression and reversibiliy
3) Key feature in terms of symptoms
4) What these patients are very sensitive to and what happens
5) Another key feature in terms of awareness
6) Pathological findings

1) Alzheimer's Disease
2) Progressive and irreversible
3) Prominent VISUAL HALLUCINATIONS and PARKINSONIAN FEATURES (i.e tremor) even early in illness
4) Very sensitive to TYPICAL ANTIPSYCHOTICS and therefore get EXTRAPYRAMIDAL SIDE EFFECTS even at low doses so these are contraindicated
5) Have periods of LUCIDNESS followed by SEVERE CONFUSION (often misdiagnosed as delirium)
6) Eosinophillic bodies (i.e Lewy bodies)

What type of dementia is characterized by severe VISUAL HALLUCINATIONS early on along with resting tremors and shuffling gait? What should not be given to them and why?

- Lewy body dementia
- Do NOT give typical antipsychotic because very likely to get extrapyramidal side effects

In terms of PICK'S DISEASE, describe:
1) Another name for it
2) Commonality
3) What it does not usually have and it usually does have
4) What it resembles later on
5) Social
6) Definitive diagnosis
7) Gender difference
8) Family history

1) Frontotemporal dementia
2) Only about 5%
3)
- EARLY ON usually has personality changes and bizzare behavior changes
- Usually no memory loss early on but later on it is present
4) Resembles Alzheimer's disease later on
5) Social dishinibition early on
6) After autopsy see FRONTOTEMPORAL ATROPHY and VENTRICULAR DILATION and PICK'S BODIES
7) More often in men
8) More often in 1st degree relatives with Pick's disease

Differentiate PICK'S DISEASE, ALZHEIMER"S DEMENTIA and LEWY BODY DEMENTIA

ALZHEIMER'S DISEASE
- Early on subtle changes but later on significant cognitive impairment

LEWY BODY DEMENTIA
- Severe visual hallucinations and parkinson's disease symptoms early on

PICK'S DISEASE (FRONTOTEMPORAL LOBE DEMENTIA)
- Significant behavioral and personality changes early on

In terms of HUNTINGON'S DISEASE, describe:
1) What type of disease it is and what it involves
2) Presentation
3) Key feature
4) Key co-morbidity and why
5) Relation to dementia

1) Autosomal dominant and involves short arm of chromosome 4
2) Wide variety (depression, anxiety, hallucinations etc.)
3) Chorieform movements later on
4) Suicidal thoughts since very poor prognosis
5) In terminal phase (congnition problems without language problems)

How does HUNTINGTON's DISEASE resemble dementia in later stages? What is a difference?

- Significant cognitive impairment
- No impairment with language

What disease is characterized by increased sucidal thoughts and chorieform movements? What is the basis of this disease?

- Huntington's disease
- Mutation of gene (autosomal dominant) on short arm of chromosome 4

In terms of CRUETZFELDT-JAKOB DISEASE, describe
1) Commonality
2) Cause
3) Peak incidence age
4) Prognosis
5) Transmission
6) Treatments
7) Symptom often seen

1) Rare
2) Prions
3) Between 50 and 70
4) Death within few months of onset
5) Transmitted via brain matter to brain matter OR inherited
6) No known treatments
7) Mild clonic jerks AND cerebellar signs (i.e ataxia)

What is a REVERSIBLE cause of dementia?

- Vascular dementia

In terms of VASCULAR DEMENTIA, describe:
1) Commonality
2) Reversibility
3) Co-occurence
4) Causes
5) Progression
6) Risk factors
7) What is treatment often
8) What patients are often prone to and why

1) Second most common
2) It is reversible
3) Can occur along with other types of dementia
4) Infarcts (of blood vessels)
5) Progression in STEP-WISE fashion (one stroke causes certain problems and stay that way for a while until another stroke causes another set of problems on top)
6) Hypertension, diabetes or arterosclerosis
7) Aspirin or other anticoagulants
8) Bleeding out because of anticoagulants they are on

What is the second most common type of dementia?

Vascular dementia

A patient comes in with a step-like fashion degeneration that resembles dementia. What type is it probably? How would you treat it?

- Vascular dementia
- Aspirin or other anticoagulants

What is disease that causes incontinence, dementia and ataxia?

Normal pressure hydrocephalus

In terms of NORMAL PRESSURE HYDROCEPHALUS, describe:
1) What it causes
2) Pathological problem
3) Treatment

1) Incotinence, ataxia and dementia (Wet, wobbly and weird)
2) Excessive accumulation of CSF
3) Insert a shunt

A patient comes in with ataxic gait and incontinence. He also has cognitive impairment and memory problems. What would be a good treatment plan and why?

- Shunt
- He probably has normal pressure hydrocephalus causing accumulation of CSF

True/False: HIV or other infections can lead to dementia even in early stages of the infection

True

Describe the differentiation in metabolic disorders causing DEMENTIA and DELIRIUM

- Acute metabolic disorders lead to DELIRIUM
- Chronic metabolic disorders lead to DEMENTIA

What is a beneficial treatment for EARLY DEMENTIA? What must be explained to the family? What three drugs are used normally? What is no longer used and why?

- Cholinergic therapies (i.e cholinesterase inhibitors)
- It will NOT stop disease or reverse it but rather just slow down the progression
- Rivastigmine, Donepazil and galantimine used
- Tacrine no longer used because of hepatotoxicity

What is another possibly beneficial treatment for dementia? What is an example?

- NMDA receptor agonist
- Memantadine

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Which of the following is a feature of delirium that can help differentiate it from dementia?

Delirium and dementia are separate disorders but are sometimes difficult to distinguish. In both, cognition is disordered; however, the following helps distinguish them: Delirium affects mainly attention. Dementia affects mainly memory.

How can you differentiate symptoms of delirium from dementia?

Memory: One of the major differences between delirium and dementia is that, while delirium affects attention and concentration, dementia is primarily associated with memory loss.

What is the most distinguishing characteristic of delirium?

Delirium is characterized by an acute change (usually over hours to days) in mental status. Patients demonstrate fluctuating levels of consciousness that they often manifest by periodically falling asleep during an interview.

What are 3 characteristics of delirium?

The CAM diagnostic algorithm evaluates four key features of delirium: 1) Acute Change in Mental Status with Fluctuating Course, 2) Inattention, 3) Disorganized Thinking, and 4) Altered Level of Consciousness.